AION  ATELIER
Methodology · Foundational citations

The literature the Othala Method inherits.

The AION Atelier methodology is grounded in the peer-reviewed literature on women’s longevity biology. The foundational citations — the framing literature for the Master Biomarker Registry — are listed below. The full reference document, including all biomarker-specific primary sources, is available on request.

i · Staging

The STRAW+10 framework.

  1. Harlow SD, Gass M, Hall JE, Lobo R, Maki P, Rebar RW, Sherman S, Sluss PM, de Villiers TJ. Executive summary of the Stages of Reproductive Aging Workshop +10: addressing the unfinished agenda of staging reproductive aging. J Clin Endocrinol Metab. 2012;97(4):1159–1168.
ii · Hormonal architecture

Ovarian, thyroid, and the endocrine arc.

  1. Aslan K, Kasapoglu I, Kosan B, Tunali A, Tellioglu I, Uncu G. Age-stratified anti-Müllerian hormone (AMH) nomogram: a comprehensive cohort study including 22,920 women. Front Endocrinol (Lausanne). 2025;16:1612194.
  2. Huang Y, Kuang X, Jiangzhou H, Li M, Yang D, Lai D. Using anti-Müllerian hormone to predict premature ovarian insufficiency: a retrospective cross-sectional study. Front Endocrinol (Lausanne). 2024;15:1454802.
  3. Jonklaas J, Bianco AC, Bauer AJ, et al. Guidelines for the treatment of hypothyroidism: prepared by the American Thyroid Association Task Force on Thyroid Hormone Replacement. Thyroid. 2014;24(12):1670–1751.
iii · Cardiovascular sex-dimorphism

The perimenopausal cardiovascular pivot.

  1. Moreau KL, Hildreth KL, Meditz AL, Deane KD, Kohrt WM. Endothelial function is impaired across the stages of the menopause transition in healthy women. J Clin Endocrinol Metab. 2012;97(12):4692–4700.
  2. Soffer DE, Marston NA, Maki KC, et al. Role of apolipoprotein B in the clinical management of cardiovascular risk in adults: an Expert Clinical Consensus from the National Lipid Association. J Clin Lipidol. 2024;18(5):e647–e663.
  3. Koschinsky ML, Bittner V, Bowden DH, et al. A focused update to the 2019 NLA scientific statement on use of lipoprotein(a) in clinical practice. J Clin Lipidol. 2024;18(3):e308–e319.
iv · Inflammation & metabolic

Systemic inflammatory signaling.

  1. Phillips MD, Patrizi RM, Cheek DJ, Wooten JS, Barbee JJ, Mitchell JB. Resistance training reduces subclinical inflammation in obese, postmenopausal women. Med Sci Sports Exerc. 2012;44(11):2099–2110.
  2. Kim M, Chang Y, Cho Y, et al. Accelerated increase in ferritin levels during menopausal transition as a marker of metabolic health. Sci Rep. 2025;15(1):29311.
v · Holistic integration

Social, environmental, and somatic determinants.

  1. Holt-Lunstad J, Smith TB, Layton JB. Social relationships and mortality risk: a meta-analytic review. PLoS Med. 2010;7(7):e1000316.
  2. Ward-Caviness CK. A review of gene-by-air pollution interactions for cardiovascular disease, risk factors, and biomarkers. Hum Genet. 2019;138(6):547–561.
  3. Blume C, Garbazza C, Spitschan M. Effects of light on human circadian rhythms, sleep and mood. Somnologie (Berl). 2019;23(3):147–156.
vi · Bone & connective

Postmenopausal skeletal architecture.

  1. The North American Menopause Society. Management of osteoporosis in postmenopausal women: the 2021 position statement of The North American Menopause Society. Menopause. 2021;28(9):973–997.
  2. Panay N, Ang SB, Cheshire R, Goldstein SR, Maki P, Nappi RE; International Menopause Society Board. Menopause and MHT in 2024: addressing the key controversies — an International Menopause Society White Paper. Climacteric. 2024;27(5):441–457.
Full reference document

The complete reference document, including all biomarker-specific primary citations across the Master Biomarker Registry, is available to clinicians, researchers, and reviewers on request.

Request the full reference document →

v1.1 · Last updated April 2026 · MMXXVI